MTHFR Gene Mutation
What This Test Measures
Detects mutations in the MTHFR gene (C677T and A1298C variants) that affect folate metabolism, homocysteine processing, and methylation. Elevated homocysteine from MTHFR variants is linked to cardiovascular risk, clotting disorders, and neural tube defects.
Preparation
General guidelines only. Requirements vary by lab and individual. Confirm with your provider before adjusting any medications.
Turnaround Time
Varies by lab
Clinical Notes
MTHFR variants affect how your body processes folate and B vitamins. Knowing your status can guide supplementation (methylfolate vs folic acid) and help explain elevated homocysteine, recurrent pregnancy loss, or cardiovascular risk. Normal result: No mutation detected (wild type). Also known as: MTHFR, MTHFR Mutation, Methylenetetrahydrofolate Reductase, MTHFR C677T, MTHFR A1298C.
Self-Pay Pricing
LabLooker may earn a commission through lab links. This does not affect pricing or rankings.
At-home self-collection. Finger prick or swab — no lab visit required. Results via secure portal within 10 business days.
Generate Doctor Request Template
Get a pre-filled template with test name, CPT code, and ICD-10 codes to bring to your appointment.
Upgrade to PremiumFor informational purposes only
This page is for educational and research purposes only and does not constitute medical advice, diagnosis, or treatment recommendations. ICD-10 and CPT codes are assigned by your healthcare provider. Always consult a qualified healthcare provider before ordering any lab test or making decisions about your health.